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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name HSP90 inhibitors
Drug Type Small molecule
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 969
Ref_1
Pair Name Piperlongumine, HSP90 inhibitors
Partner Name Piperlongumine
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress
Gene Regulation Up-regulation Expression ATF4 hsa468
Up-regulation Expression DDIT3 hsa1649
Up-regulation Expression HSPA5 hsa3309
Up-regulation Phosphorylation MAPK8 hsa5599
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
RKO Colon carcinoma Homo sapiens (Human) CVCL_0504
HCT 15 Colon adenocarcinoma Homo sapiens (Human) CVCL_0292
In Vivo Model HCT 116 cells were injected subcutaneously into the flank of athymic BALB/c nude mice (female, five weeks old). The total number of nude mice is set to 24, based on our previous experience.
Result Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells
03. Reference
No. Title Href
1 Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells. Cell Death Discov. 2023 Oct 13;9(1):375. doi: 10.1038/s41420-023-01672-y. Click
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